09-P078 Wing heart integrity depends on the cardiogenic transcription factor hand in Drosophila
نویسندگان
چکیده
09-P076 A rhombomere 4-derived auditory circuitry is dependent on Hoxb1 function Maria Di Bonito, Marta Mancuso, Gennaro Andolfi, Anna Maria Franz, Luigi Sequino, Luis Puelles, Michle Studer Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy Institute of Genetics and Biophysics, IGB A. Buzzati Traverso, Naples, Italy Universit degli Studi di Napoli Federico II, Naples, Italy Head Dept. Human Anatomy and Psychobiology, Fac. Medicine, Univ. Murcia, Murcia, Spain
منابع مشابه
The bHLH Transcription Factor Hand Regulates the Expression of Genes Critical to Heart and Muscle Function in Drosophila melanogaster
Hand proteins belong to the highly conserved family of basic Helix-Loop-Helix transcription factors and are critical to distinct developmental processes, including cardiogenesis and neurogenesis in vertebrates. In Drosophila melanogaster a single orthologous hand gene is expressed with absence of the respective protein causing semilethality during early larval instars. Surviving adult animals s...
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Vertebrate and insect (Drosophila) hearts look and function quite differently from each other. Nevertheless, during embryogenesis their mesodermal origin and initial assembly into a linear heart tube are comparable in many respects. In the past few years, numerous gene functions have been identified that are utilized by both vertebrates and Drosophila for the specification and differentiation o...
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During heart formation, a network of transcription factors and signaling pathways guide cardiac cell fate and differentiation, but the genetic mechanisms orchestrating heart assembly and lumen formation remain unclear. Here, we show that the small GTPase Cdc42 is essential for Drosophila melanogaster heart morphogenesis and lumen formation. Cdc42 genetically interacts with the cardiogenic trans...
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The regulation of cardiac gene expression by GATA zinc finger transcription factors is well documented in vertebrates. However, genetic studies in mice have failed to demonstrate a function for these proteins in cardiomyocyte specification. In Drosophila, the existence of a cardiogenic GATA factor has been implicated through the analysis of a cardial cell enhancer of the muscle differentiation ...
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The mammalian growth factor TGFbeta negatively regulates cell proliferation in various systems. Here we provide evidence that another TGFbeta superfamily member, Drosophila Decapentaplegic (Dpp), stimulates cell proliferation. In the developing wing blade, somatic clones lacking the Dpp receptors Punt or Thick veins (Tkv), or lacking Schnurri, a transcription factor involved in Dpp signal inter...
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ورودعنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009